Scientists identify the genes linked to left-handedness | CNN
Discover the latest scientific breakthroughs in understanding why some people are left-handed. Learn how genes and brain development play a key role in this fascinating trait.
Left-handedness has long been a mystery, but recent scientific advancements are shedding light on its genetic origins. About 10% of the global population is left-handed, and researchers are now uncovering the genetic and developmental factors that contribute to this trait. In this article, we’ll explore the latest findings, including the role of tubulin genes and early brain development, to help you understand the science behind left-handedness.
Why Is Left-Handedness So Rare?
Left-handedness is relatively uncommon, with only about 10 out of 100 people being left-handed. For years, scientists have been intrigued by what causes this trait. While environmental factors like prenatal conditions have been considered, genetics now appear to play a significant role.
Studies show that left-handedness often runs in families. For example, two left-handed parents are more likely to have a left-handed child compared to two right-handed parents. This suggests that handedness is influenced, at least in part, by genetic factors.
New Insights into the Genetics of Left-Handedness
Recent research has made significant progress in understanding the genetic basis of left-handedness. A groundbreaking study published in Trends in Genetics (Ocklenburg et al., 2025) synthesized findings from multiple studies to identify key genetic factors. Here’s what the research revealed:
1. Common Genetic Variants
Common genetic variants, present in at least 1% of the population, have been linked to left-handedness. These variants are small changes in DNA that can influence traits like handedness.
2. Rare Genetic Variants
Rare genetic variants, found in less than 1% of people, can also play a role. These include unique mutations that may have a strong impact on handedness, even if they occur in only a few individuals.
3. Epigenetic Factors
Epigenetics, which involves changes in gene expression rather than the DNA sequence itself, also contributes to left-handedness. These factors can influence how genes are activated or deactivated during development.
The Role of Tubulin Genes in Left-Handedness
One of the most exciting discoveries is the role of tubulin genes in left-handedness. Tubulins are proteins that play a critical role in brain development. Here’s how they influence handedness:
- Axon Growth: Tubulins help axons, the long projections of nerve cells, grow and transmit information.
- Axon Guidance: They ensure axons are organized correctly during brain development.
- Motile Cilia Structure: Tubulins help build motile cilia, which are essential for establishing left-right asymmetries in the body and brain.
These findings highlight the importance of early brain development in determining handedness.
Why Early Brain Development Matters
The research underscores that the key to understanding left-handedness lies in the early stages of brain development. Tubulin genes and other genetic factors influence how the brain’s structure and connectivity are established, ultimately shaping whether a person becomes left-handed or right-handed.
Key Takeaways
- Left-handedness affects about 10% of the population.
- Genetics, particularly tubulin genes, play a significant role in determining handedness.
- Early brain development processes, such as axon growth and cilia formation, are crucial.
- Both common and rare genetic variants, as well as epigenetic factors, contribute to left-handedness.
Explore More About Left-Handedness
The science of left-handedness is evolving rapidly, and these breakthroughs offer exciting new insights into what makes us unique. Whether you’re left-handed or simply curious about the genetics behind this trait, there’s always more to learn.
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By understanding the genetics of left-handedness, we not only solve a long-standing mystery but also gain a deeper appreciation for the complexity of human biology. Share this article with others who might find it interesting, and let’s continue exploring the wonders of science together!
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